Intracranial Pressure Monitor Enhancement For Cerebral Hemodynamic Monitoring
Continuously monitor changes in blood flow and vascular reactivity.
Project at a Glance
Product Type:
Device
Project Start Date:
July 1, 2017
Principal Investigators:
Kenn Oldham, PhD
Hakam Tiba, MD, MS
Craig Williamson, MD
Kevin Ward, MD
Solution Sheet:
Download Solution Sheet (PDF)
Intellectual Property:
Invention Disclosure # 2018-471
Patent Application Filed
Funding History:
$223,285 in non-dilutive funding • 2018 $104,433 Massey Grand Challenge
• 2022 $118,852 Massey Grand Challenge • Substantial departmental, school and center based support
Overview
A team of University of Michigan researchers is enhancing an existing intracranial pressure (ICP) monitor with miniature piezoelectric pressure and optical blood volume sensors that provide synchronized, high-bandwidth measurements of heartbeat-to-heartbeat local pressure and blood volume fluctuations. This combination of signals has been demonstrated to permit close tracking of relative constriction or dilation of peripheral arteries when applied in a non-invasive form factor, which then permits measurement of changes in blood flow given knowledge of arterial pressure and observation of certain autoregulation phenomena.
Image credit: ShutterStock
Significant Need
Current therapies for traumatic brain injury (TBI) primarily attempt to avoid secondary ischemic injuries, which are mediated by decreased cerebral blood flow due to elevated intracranial pressure and impaired cerebral autoregulation. However, there is currently no reliable method for continuously monitoring cerebral blood flow used in TBI management.
Competitive Advantage
• Sensing and flow estimation would allow clinicians to determine whether regional blood flow is increasing, stable, or decreasing in response to interventions or as the body’s response to trauma progresses
• The modified ICP monitoring catheter will be nearly identical after modification to its existing form factor
• Enables monitoring of blood flow in the region of the ICP monitor in addition to the monitor’s standard pressure measurement without altering the standard TBI workflow
Funding Organization(s)
Publications
None at this time